Omegaven Adverse Reactions

The infusion of Omegaven can lead to a prolonged bleeding time and an inhibited platelet aggregation. In rare cases, patients may experience a fishy taste.
Adverse Reactions Observed During the Administration of Fat Emulsions: Slight increase in body temperature; heat and/or cold sensations; chills; flush or cyanosis; lack appetite, nausea, vomiting; dyspnoea; headache, pain in the chest, back and loins, bone pain; priapism (in very rare cases); increase or decrease in blood pressure; anaphylactic reactions (eg, erythema).
Possible signs of metabolic overload must be observed. The cause may be genetic (individually different metabolisms) and with respect to different previous illnesses with varying rapidity and following different  doses, but has been observed mainly with the use of cottonseed oil emulsions.
Metabolic Overload Might Give the Following Symptoms: Hepatomegaly with or without icterus; a change or reduction of some coagulation parameters (eg, bleeding time, coagulation time, prothrombin time, platelet count); splenomegaly; anaemia, leukopenia, thrombocytopenia; bleedings and tendency to bleed; pathological liver function tests; fever; hyperlipidaemia; headache, stomach pains, fatigue; hyperglycemia.
Should these adverse reactions occur or should the triglyceride level during lipid infusion rise >3 mmol/L, the lipid infusion should be stopped or, if necessary, continued at a reduced dosage.