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Indications and Dosage
Vaginal
Contraception Adult: As a barrier spermicidal contraceptive: Alone or in conjunction with barrier methods of contraception (e.g. diaphragms or caps): As 28% film: Insert 1 film into the vagina at least 15 minutes to <3 hours before the intercourse; insert new film for each act of intercourse. As 1,000 mg sponge: Insert 1 sponge into the vagina prior to intercourse; allow to remain in place for 6 hours after intercourse. Do not leave in place for >30 hours.
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Contraindications
Patient with HIV/AIDS or those whose sexual partner is infected with HIV/AIDS. Sponge: History of toxic shock syndrome; within 6 weeks after giving birth; during menstrual period.
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Special Precautions
Patient who had a recent miscarriage or an abortion or with vaginal or uterine condition (e.g. vaginal septum or uterine prolapse), multiple sex partners, new partner, or unprotected sex (sponge). Nonoxinol 9 does not provide protection against HIV infection or other STDs; use may increase the risk of acquiring HIV from an infected sexual partner. Pregnancy and lactation.
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Adverse Reactions
Significant: Vaginal irritation (e.g. burning, itching, rash).
Potentially Fatal: Rarely, toxic shock syndrome (sponge). |
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Action
Description:
Mechanism of Action: Nonoxinol 9, a nonionic surfactant, damages the cell membrane of the sperm, causing a rapid loss of motility and function, which leads to sperm death. This action results in the prevention of pregnancy. Synonym(s): Nonoxynol 9. |
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Storage
Store between 15-30°C.
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MIMS Class
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References
Brayfield A, Cadart C (eds). Nonoxinols. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/05/2025. Joint Formulary Committee. Nonoxinol. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/05/2025. Nonoxinol 9 [Nonoxynol 9]. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 09/05/2025. Nonoxynol-9. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 20/05/2025. Today Vaginal Contraceptive Sponge (Mayer Laboratories, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 09/05/2025. VCF Contraceptive Film, Soluble (Apothecus Pharmaceutical Corp.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 09/05/2025.
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