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Occasionally, the onset of side effects affecting the gastroenteric system has been observed i.e. pyrosis, nausea and gastralgia, usually mild and transitory. Allergic reactions are relatively frequent usually erythematous or urticarioid skin rashes. CNS symptoms are reported, such as headache, dizziness, and drowsiness.
Other rarely observed side effects are oliguria, with or without water retention and localized or diffused oedema, melena (probably correlated with possible gastro-intestinal ulcers and haemorrhages), petacchiae and purpura especially in the lower limbs, associated with thrombocytopenia. Even if no case has been reported for nimesulide, it should be remembered that as in the case of other non-steroidal anti-inflammatory drugs, the product can trigger severe hypersensitivity reactions, e.g., Steven-Johnson syndrome. Lyell syndrome, anaphylactic reactions and possibly risk of stomatitis.
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