Intralipid 20% Special Precautions

Intralipid 20% should be given with caution in conditions of impaired lipid metabolism as in renal insufficiency, uncompensated diabetes mellitus, pancreatitis, impaired liver function, hypothyroidism (if hypertriglyceridemic) and sepsis. If Intralipid 20% is given to patients with these conditions, close monitoring of the serum triglyceride concentration is obligatory.
Patients known to be allergic to soy or egg proteins should be given Intralipid 20% with great caution and only after hypersensitivity tests.
Intralipid 20% should be given with caution to neonates and prematures with hyperbilirubinemia and cases with suspected pulmonary hypertension. In neonates, particularly prematures on long-term parenteral nutrition, platelet count, liver test and serum triglyceride concentration should be monitored.
Intralipid 20% may interfere with certain laboratory measurements (bilirubin, lactate dehydrogenase, oxygen saturation, hemoglobin) if blood is sampled before fat has been adequately cleared from the bloodstream. Fat is cleared after a fat-free interval of 5-6 hrs in most patients.
Use in pregnancy & lactation: No adverse events during pregnancy and lactation has been reported.