Intralipid 20% Adverse Reactions

Intralipid 20% infusion may cause a rise in body temperature and less frequently, shivering, chills and nausea/vomiting (incidence <1%).
Reports of other adverse events in conjunction with Intralipid 20% infusion are extremely rare,  less than 1 adverse event per 1 million infusions. See table.

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Thrombocytopenia has been reported in association with prolonged treatment with Intralipid 20% in infants.
Transient increase in liver function tests after prolonged IV nutrition with or without Intralipid 20% have also been noted. Increased cholesterol has been observed with infants after long-term treatment with Intralipid 20%. The reasons are not clear at present.
Fat Overload Syndrome: An impaired capacity to eliminate Intralipid 20% may lead to the fat overload syndrome as a result of overdosage. However, this syndrome may also appear at recommended rates of infusion in association with a sudden change in the patient's clinical condition eg, renal function impairment or infection. The fat overload syndrome is characterised by hyperlipemia, fever, fat infiltration and disorders in various organs and coma. All symptoms are usually reversible if the infusion of Intralipid 20% is discontinued.