Hidroferol Drug Interactions

Phenytoin, phenobarbital, primidone and other enzyme inducers: Enzyme inducers may reduce plasma concentrations of calcifediol and inhibit its effects by inducing its hepatic metabolism. For this reason it is generally recommended to monitor plasma 25-OH-D levels when calcifediol is administered with antiepileptics that are CYP3A4 inducers in order to consider supplementation.
Cardiac glycosides: Calcifediol can cause hyperglycemia, which can, in turn, enhance the inotropic effects of digoxin and its toxicity, producing cardiac arrhythmias.
Cholestyramine, colestipol or orlistat: Drugs that decrease the absorption of calcifediol such as cholestyramine, colestipol or orlistat, can result in decreased effects. It is recommended to space doses of these medicines and vitamin D supplements at least 2 hours.
Paraffin and mineral oil: Due to liposolubility of calcifediol, the product can dissolve in paraffin and intestinal absorption may decrease. Using other types of laxatives or at least spacing doses is recommended.
Thiazide diuretics: Co-administration of a thiazide diuretic (hydrochlorothiazide) with vitamin D supplements in patients with hypoparathyroidism may lead to hypercalcemia, which may be temporary or require the interruption of the treatment with the vitamin D analogue.
Penicillin, neomycin and chloramphenicol: Some antibiotics, such as penicillin, neomycin and chloramphenicol can increase calcium absorption.
Phosphate-binding agents such as magnesium salts: Since vitamin D has an effect on phosphate transport in the intestine, kidney and bone, hypermagnesemia may occur. The dosage of agents that bind to phosphate shall be adjusted according to phosphate concentrations in serum.
Verapamil: Some studies show potential inhibition of antianginal action, due to antagonism of their actions.
Vitamin D: Co-administration of any vitamin D analogue should be avoided as additive effects and hypercalcemia can occur.
Calcium supplements: Uncontrolled intake of additional preparations containing calcium should be avoided.
Corticosteroids: They counteract the effects of vitamin D analogue drugs such as calcifediol.
Interaction with food and drinks: Food supplemented with vitamin D should be taken into account, since additive effects may occur.