Carboplatin Pharmachemie Overdosage

Since no known antidote exists for carboplatin, every possible measure should be undertaken to avoid an overdose.
The following are general guidelines in the avoidance of overdosage of anticancer agents: Chemotherapy should only be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents.
Adequate diagnostic and treatment facilities must be readily available to ensure appropriate management and treatment of possible complications.
All personnel involved in handling chemotherapeutic agents should be fully knowledgeable of the potential dangers. Administration of these drugs should never be considered a routine task.
Charts of normal doses of chemotherapeutic agents should be available in all nursing stations and wherever drugs are prepared or administered.
Dosage should be carefully calculated as mg/kg or mg/m², as applicable, and recorded in a chart. The chart should include the total dose expressed as concentration in the total volume to be administered.
Manifestations: The anticipated complications of overdosage would be secondary to bone marrow suppression and/or hepatic toxicity.
Treatment: There is no known antidote for carboplatin. Symptomatic measures should be taken to sustain the patient through any period of toxicity that might occur.