Carboplatin Pharmachemie Caution For Usage

Dilution of Carboplatin Injection: Carboplatin Injection may be diluted to the required strength with Water for Injection, 5% Dextrose Injection, or 0.9% Sodium Chloride Injection, to concentrations as low as 0.5 mg/ml. The resulting solution is stable for 12 hours when stored at room temperature protected from light or for 36 hours when stored in a refrigerator.
Handling and Disposal: As with all cytotoxic preparations, the following special precautions should be taken for safe handling and disposal: Trained personnel should only reconstitute the drug. Pregnant staff should not be involved in its handling.
Preparation of the drug should be performed in a designated area, ideally in a vertical laminar flow hood (Biological Safety Cabinet - Class II). The work surface should be covered with disposable plastic-backed absorbent paper.
Adequate protective clothing should be worn, i.e. PVC gloves, safety glasses, disposable gowns and masks. In the event of contact with the eyes, wash with copious amounts of water or saline.
Luer-Lock fittings should be used on all syringes and sets. The possible formation of aerosols may be reduced by using large-bore needles and venting needles.
All unused material, needles, syringes, vials and other items which have come into contact with cytotoxic drugs should be segregated, placed in double-sealed polyethylene bags and incinerated at 1000°C or more. Excreta should be similarly treated. Liquid waste should be flushed away with copious amounts of water.