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Symptoms: Overdosage can cause symptoms like headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, rarely diarrhoea, dizziness, disorientation, excitation, coma, drowsiness, tinnitus, fainting, or convulsions. In rare cases of significant poisoning acute renal failure and liver damage are possible.
Management: Supportive measures and symptomatic treatment should be used for complications such as hypotension, renal failure, convulsions, gastrointestinal disturbances, and respiratory failure.
Special measures such as diuresis, hemodialysis, or blood transfusion are unlikely to be effective in removing NSAIDs, including diclofenac, due to their high protein binding and extensive metabolism.
Activated charcoal can be used after overdose, potentially toxic, and gastric detox (eg, induce vomiting, gastric lavage) after a potentially life-threatening overdose.
Frequent or prolonged convulsions should be treated with intravenous diazepam. Other measures may be indicated by the patient's clinical condition.
