Betamethasone + Salicylic acid

Hypersensitivity. Skin tuberculosis, viral lesions of the skin (e.g. vaccinia, varicella, herpes simplex), fungal or bacterial skin infections, napkin eruptions, acne, rosacea, perioral dermatitis, perianal and genital pruritus.

Patient with psoriasis. Avoid long-term continuous treatment particularly in extensive body surface areas or skin folds. Limit use to 5 days when applied on the face. Children. Pregnancy and lactation.

Significant: Adrenal suppression, hyperglycaemia, glucosuria; HPA axis suppression, Cushing's syndrome, linear growth retardation, delayed weight gain, intracranial hypertension (particularly in children); visual disturbances (e.g. blurred vision); topical steroid withdrawal reactions (withdrawal after long-term use), may be manifested as severe redness which can spread beyond the initial affected area, itching, burning or stinging sensation, and skin peeling; salicylism.
Skin and subcutaneous tissue disorders: Local skin atrophy, striae, superficial vascular dilation (particularly on the face); burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration.

Avoid contact with the eyes or mucous membranes. Do not use occlusive dressings unless directed by the doctor.

Monitor HPA axis suppression and adrenal insufficiency (particularly in children).

Symptoms: Betamethasone: Suppression of pituitary-adrenal functions leading to secondary adrenal insufficiency; manifestation of hypercorticism including Cushing's disease. Salicylic acid: Salicylism. Management: Symptomatic treatment. Treat electrolyte imbalance, if needed. In case of chronic toxicity, slowly withdraw the use of the product. Employ measures to remove the salicylate from the body. Administer oral Na bicarbonate to alkalinise the urine and force diuresis.

Betamethasone: May suppress the wheal and flare reactions to skin test antigens.

Description:
Mechanism of Action: Betamethasone is a synthetic fluorinated corticosteroid. It is active topically and may reduce the production, release, and action of endogenous chemical mediators (including kinins, histamine, liposomal enzymes, prostaglandins) by inducing phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibiting the release of arachidonic acid. Betamethasone has an intermediate to very high range of potency.
Salicylic acid is a keratolytic agent. It produces desquamation of hyperkeratotic epithelium by dissolving the intercellular cement, leading to swelling, softening, maceration, and desquamation of the cornified tissue.

Pharmacokinetics:
Absorption: Betamethasone: Absorbed percutaneously.
Salicylic acid: Readily absorbed after topical application.
Distribution: Crosses the placenta.
Salicylic acid: Plasma protein binding: 50-80%, mainly to albumin.
Metabolism: Betamethasone: Metabolised in the liver.
Excretion: Betamethasone: Via urine and bile.
Salicylic acid: Via urine (52% as salicyluric acid, 42% as salicylate glucuronides, 6% as salicylic acid).

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 9782, Betamethasone. https://pubchem.ncbi.nlm.nih.gov/compound/Betamethasone. Accessed Sept. 24, 2024.

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 338, Salicylic Acid. https://pubchem.ncbi.nlm.nih.gov/compound/Salicylic-Acid. Accessed Oct. 25, 2024.

Store between 15-30°C. Protect from light.

Thuốc kháng khuẩn có corticoid dùng tại chỗ

D07XC01 - betamethasone ; Belongs to the class of potent (group III) corticosteroids in other combinations. Used in the treatment of dermatological diseases.

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