Zinvel Indications/Uses

Hypercalcemia of Malignancy (HCM): Treatment of moderate to severe hypercalcemia of malignancy [albumin-corrected calcium (cCa) of ≥12 mg/dL (≥3 mmol/L)] using the formula: cCa in mg/dL=Ca in mg/dL + 0.8 (mid-range of measured albumin in mg/dL).
Multiple Myeloma and Bone Metastases of Solid Tumors: Treatment of osteolytic, osteoblastic, and mixed bone metastases of solid tumors and osteolytic lesion of multiple myeloma, in conjunction with standard antineoplastic therapy. In patients with bone metastases associated with prostate cancer, zoledronic acid should be used as 2nd-line therapy and is reserved for those with disease progression following ≥1 hormonal therapies.
Reduction of bone damage in patients with advanced malignancies involving bone.
Important Limitation of Use: The safety and efficacy of zoledronic acid in the treatment of hypercalcemia associated with hyperparathyroidism or with other non-tumor related conditions has not been established.