Vectibix Dosage/Direction for Use

Posology: VECTIBIX treatment should be supervised by a physician experienced in the use of anti-cancer therapy.
RAS mutational status should be determined by an experienced laboratory using a validated test method.
Recommended dose: 6 mg/kg bodyweight given once every 2 weeks.
Prior to infusion, VECTIBIX should be diluted in 0.9% sodium chloride to a final concentration not to exceed 10 mg/mL (for preparation instructions see Special instructions for use and handling under Cautions for Usage).
DOSE MODIFICATIONS - INFUSION REACTIONS: See Infusion reactions under Precautions. Reduce infusion rate by 50% in patients experiencing a mild or moderate (grade 1 or 2) infusion reaction for the duration of that infusion.
Stop infusion if a severe or life-threatening infusion reaction occurs and depending on the severity and/or persistence of the reaction, consider permanently discontinuing VECTIBIX.
DOSE MODIFICATIONS - DERMATOLOGIC TOXICITY: See Table 8.

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MANAGEMENT OF SKIN TOXICITIES: Proactive skin treatment including skin moisturizer, sunscreen (SPF > 15 UVA and UVB), topical steroid cream (not stronger than 1% hydrocortisone) and an oral antibiotic, as prescribed by the physician, may be useful in the management of skin toxicities. Patients may be advised to apply moisturizer and sunscreen to face, hands, feet, neck, back and chest every morning during treatment, and to apply the topical steroid to face, hands, feet, neck, back and chest every night. Treatment of skin reactions should be based on severity and may include a moisturizer, sunscreen (SPF > 15 UVA and UVB), and topical steroid cream (not stronger than 1% hydrocortisone) applied to affected areas, and/or oral antibiotics, as prescribed by the physician.
Method of administration: VECTIBIX must be administered as an intravenous (IV) infusion via an infusion pump, using a low protein binding 0.2 or 0.22 micrometer in-line filter, through a peripheral line or indwelling catheter.
The recommended infusion time is approximately 60 minutes. Doses higher than 1,000 mg should be infused over approximately 90 minutes. The infusion line should be flushed with 0.9% sodium chloride solution before and after VECTIBIX administration to avoid mixing with other medicinal products or IV solutions.
Do not administer VECTIBIX as an IV push or bolus.
For instructions on dilution of the medicinal product before administration, see Special instructions for use and handling under Cautions for Usage.