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Each film-coated tablet also contains the following excipients: Low substituted hydroxypropylcellulose, hydroxypropylcellulose, corn starch, magnesium stearate, talc, D-mannitol, hypromellose, titanium oxide and carnauba wax.
Silodosin is (-)-l-(3-Hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl} amino) propyl]-2,3-dihydro-1H-indole-7-carboxamide.
It has a molecular formula of C25H32F3N3O4 and a molecular weight of 495.53.
Silodosin is freely soluble in methanol and ethanol (99.5), and very slightly soluble in water with a melting point of 105-109°C.
Silodosin has a partition coefficient, distribution ratio (l-octanol/buffer) of 4.1 x 10-3 at pH 2.8, 1.7 at pH 6 and 5 x 102 at pH 9.7.
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