Truxima Caution For Usage

Special Instructions for Use, Handling and Disposal: Withdraw the required amount of Truxima under aseptic conditions and dilute to a calculated rituximab concentration of 1 - 4 mg/mL in an infusion bag containing sterile, non-pyrogenic 0.9%, aqueous saline solution or 5% aqueous dextrose solution. To mix the solution, gently invert the bag to avoid foaming. Care must be taken to ensure the sterility of prepared solution. Since the medicinal product does not contain any anti-microbial preservative or bacteriostatic agents, aseptic technique must be observed. Parenteral medications should be inspected visually for particulate matter or discoloration prior to administration.
The prepared infusion solution of Truxima is physically and chemically stable for 24 hours at 2°C - 8°C and subsequently 12 hours at room temperature.
Incompatibilities: No incompatibilities between rituximab and polyvinyl chloride or polyethylene bags or infusion sets have been observed.
Disposal of unused/expired medicines: The release of pharmaceuticals in the environment should be minimized. Medicines should not be disposed of via wastewater and disposal through household waste should be avoided. Use established "collection systems", if available in the location.