Sitagliptin-Plus Sandoz Contraindications

Sitagliptin-Plus Sandoz (sitagliptin phosphate/metformin HCl) is contraindicated in patients with: hypersensitivity to the active substances or to any of the excipients listed in Description (see Precautions and Adverse Reactions); acute or chronic metabolic acidosis, including lactic acidosis, diabetic ketoacidosis, with or without coma; diabetic pre-coma; severe renal failure (GFR <30 mL/min) (see Precautions); acute conditions with the potential to alter renal function such as: dehydration, severe infection, shock, intravascular administration of iodinated contrast agents (see Precautions); acute or chronic disease which may cause tissue hypoxia such as: cardiac or respiratory failure, recent myocardial infarction, shock; hepatic impairment; acute alcohol intoxication, alcoholism; Sitagliptin-Plus Sandoz should be temporarily discontinued in patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials, because the use of such products may result in acute alteration of renal function; breast-feeding.