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No interaction studies have been performed.
In rheumatoid arthritis, psoriatic arthritis and Crohn's disease patients, there are indications that concomitant use of methotrexate and other immunomodulators reduces the formation of antibodies against infliximab and increases the plasma concentrations of infliximab. However, the results are uncertain due to limitations in the methods used for serum analyses of infliximab and antibodies against infliximab.
Corticosteroids do not appear to affect the pharmacokinetics of infliximab to a clinically relevant extent.
The combination of Remsima with other biological therapeutics used to treat the same conditions as Remsima, including anakinra and abatacept, is not recommended (see Precautions).
It is recommended that live vaccines not be given concurrently with Remsima (see Precautions).
It is recommended that therapeutic infectious agents not be given concurrently with Remsima (see Precautions).
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