Specific reversal agent for dabigatran & in adults treated w/ dabigatran when rapid reversal of its anticoagulant effects is required for emergency surgery/urgent procedures & in life-threatening or uncontrolled bleeding.
IV Recommended dose: 5 g (2 x 2.5 g/50 mL) administered as 2 consecutive infusions over 5-10 min each or as bolus inj. Bleeding recurrence/potential life-threatening re-bleeding/2nd emergency surgery or urgent procedure & have prolonged clotting times Consider 2nd 5 g dose. Restarting antithrombotic therapy Re-initiate Pradaxa 24 hr after administration of Praxbind & other antithrombotic therapy (eg, LMWH) at any time if patient is clinically stable & adequate haemostasis has been achieved.
Discontinue treatment immediately if anaphylactic or other serious reaction occurs. Consider resumption of anticoagulant therapy in patients treated w/ dabigatran that may have underlying disease states predisposing to thromboembolic events. May cause transient proteinuria. Patients on controlled Na diet. Hereditary fructose intolerance. Pregnancy & lactation. Childn <18 yr.
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