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Overdoses of Topiramate have been reported. Signs and symptoms included convulsions, drowsiness, speech disturbances, blurred vision, diplopia, impaired mentation, lethargy, abnormal coordination, stupor, hypotension, abdominal pain, agitation, dizziness and depression. The clinical consequences were not severe in most cases, but deaths have been reported after overdoses with multiple medicinal products including Topiramate.
Topiramate overdose can result in severe metabolic acidosis.
Treatment: In acute Topiramate overdose, if the ingestion is recent, the stomach should be emptied immediately by lavage or by induction of emesis. Activated charcoal has been shown to adsorb Topiramate in vitro. Treatment should be appropriately supportive and the patient should be well hydrated. Hemodialysis has been shown to be an effective means of removing Topiramate from the body.
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