Pentaglobin Dosage/Direction for Use

Posology: The dosage is dependent on the patient's immune status and on the severity of the disease. The following dosage suggestions may be used as reference: Neonates and infants: 5 ml (0.25 g)/kg body weight daily on 3 consecutive days. Further infusions may be required depending on the clinical course.
Children and adults: a) Therapy of severe bacterial infections: 5 ml (0.25 g)/kg body weight daily on 3 consecutive days.
Further infusions may be required depending on the clinical course.
b) Immunoglobulin substitution in immunocompromised patients and in severe secondary antibody deficiency syndrome patients: 3-5 ml (0.15-0.25 g)/kg body weight. Repetition at weekly intervals, if necessary.
Pentaglobin should be infused intravenously at the following rates: in neonates and infants: 1.7 ml/kg body weight/hour by infusion pump; in children and adults: 0.4 ml/kg body weight/hour.
Alternatively: the first 100 ml at 0.4 ml/kg body weight/hour then 0.2 ml/kg body weight/hour continuously until 15 ml/kg body weight is reached within 72 hours. (See Table 1.)

Click on icon to see table/diagram/image

Hepatic impairment: No evidence is available to require a dose adjustment.
Renal impairment: No dose adjustment unless clinically warranted, see Precautions.
Elderly: No dose adjustment unless clinically warranted, see Precautions.
Method of administration: Intravenous use.
Pentaglobin should be brought to room or body temperature before use.