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Overdose and Treatment: There is no specific antidote for olanzapine. Induction of emesis is not recommended. Standard procedures for management of overdose may be indicated (i.e. gastric lavage, administration of activated charcoal). The concomitant administration of activated charcoal was shown to reduce the oral bioavailability of olanzapine by 50-60%.
Use the multiple-dose activated charcoal, hemoperfusion, forced diuresis, and urinary alkalinization, is lacking; however, these treatments are unlikely to be beneficial following olanzapine overdosage because of the drug's large volume of distribution and extensive protein binding.
Symptomatic treatment and monitoring of vital organ function should be instituted according to clinical presentation, including treatment of hypotension and circulatory collapse and support of respiratory function.
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