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Symptoms: Limited information is available on the acute toxicity of minoxidil. Severe hypotension after ingestion of minoxidil is most likely to occur in patients with residual sympathetic nervous system blockade from previous therapy with guanethidine or α-adrenergic blockers.
Treatment: In these patients, IV administration of 0.9% sodium chloride injection helps maintain blood pressure and facilitates urine formation. Norepinephrine and epinephrine should be avoided, and vasopressors such as phenylephrine, vasopressin, and dopamine should be used only if a vital organ is underperfused.
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