Neurica Adverse Reactions

Very common: >10%.
Cardiovascular: Peripheral edema.
Endocrine & metabolic: Weight gain.
Gastrointestinal: Xerostomia.
Nervous system: Dizziness, drowsiness, fatigue, headache.
Ophthalmic: Blurred vision, visual field loss.
Common: 1-10%.
Cardiovascular: Chest pain, edema, facial edema, hypertension, hypotension.
Dermatologic: Contact dermatitis, ecchymoses, pressure ulcer.
Endocrine & metabolic: Decreased libido, fluid retention, hypoglycemia.
Gastrointestinal: Abdominal distension, abdominal pain, constipation, diarrhea, flatulence, gastroenteritis, increased appetite, nausea, sialorrhea, viral gastroenteritis, vomiting.
Genitourinary: Erectile dysfunction, impotence, urinary frequency, urinary incontinence, urinary tract infection.
Hematologic & oncologic: Thrombocytopenia (including severe thrombocytopenia).
Hepatic: Increased serum alanine aminotransferase, increased serum aspartate aminotransferase.
Hypersensitivity: Hypersensitivity reaction.
Infection: Infection, viral infection.
Nervous system: Abnormal gait, abnormality in thinking, amnesia, anorgasmia, ataxia, balance impairment, confusion, depersonalization, disorientation, disturbance in attention, euphoria, feeling abnormal, hypertonia, hypoesthesia, insomnia, intoxicated feeling, lethargy, memory impairment, myasthenia, nervousness, neuropathy, pain, paresthesia, sedated state, speech disturbance, stupor, twitching (includes myokymia), vertigo.
Neuromuscular & skeletal: Arthralgia, asthenia, increased creatine phosphokinase in blood specimen, joint swelling, lower limb cramp, muscle spasm, tremor.
Ophthalmic: Conjunctivitis, decreased visual acuity, diplopia, eye disease, nystagmus disorder, visual disturbance.
Otic: Otitis media, tinnitus.
Respiratory: Bronchitis, dyspnea, flu-like symptoms, nasopharyngitis, pharyngolaryngeal pain, pneumonia, respiratory tract infection, sinusitis.
Miscellaneous: Accidental injury, fever.
Uncommon: <1%.
Cardiovascular: Cardiac failure, depression of ST segment on ECG, orthostatic hypotension, palpitations, retinal vascular disease, shock, syncope, tachycardia, thrombophlebitis, ventricular fibrillation.
Dermatologic: Alopecia, cellulitis, cutaneous nodule, dermal ulcer, eczema, erythema of skin, exfoliative dermatitis, lichenoid dermatitis, nail disease, pustular rash, skin atrophy, skin blister, skin necrosis, skin photosensitivity, skin rash, Stevens-Johnson syndrome, subcutaneous nodule, urticaria, vesiculobullous dermatitis, xeroderma.
Endocrine & metabolic: Albuminuria, decreased glucose tolerance, glycosuria, increased libido.
Gastrointestinal: Ageusia, aphthous stomatitis, cholecystitis, cholelithiasis, colitis, dry mucous membranes, dysgeusia, dysphagia, esophageal ulcer, esophagitis, gastritis, gastrointestinal hemorrhage, hiccups, increased serum lipase, melena, oral mucosa ulcer, oral paresthesia, pancreatitis, periodontal abscess.
Genitourinary: Ejaculatory disorder, oliguria, pelvic pain, proteinuria, retroperitoneal fibrosis, urate crystalluria, urinary retention, urine abnormality, uterine hemorrhage.
Hematologic & oncologic: Anemia, eosinophilia, granuloma, hemophthalmos, hypochromicanemia, hypoprothrombinemia, increased neutrophils, leukocytosis, leukopenia, lymphadenopathy, myelofibrosis, nonthrombocytopenic purpura, petechial rash, polycythemia, purpuric rash, rectal hemorrhage, thrombocythemia (rare).
Hepatic: Ascites.
Hypersensitivity: Angioedema.
Infection: Abscess.
Local: Local inflammation (coccygodynia).
Nervous system: Abnormal dreams, agitation, apathy, aphasia, cerebellar syndrome, chills, cognitive dysfunction, cogwheel rigidity, delirium, delusion, drug dependence, dysarthria, dysautonomia, dystonia, encephalopathy, extraocular palsy, extrapyramidal reaction, hallucination, hangover effect, hostility, hypoalgesia, hyperalgesia, hyperesthesia, hypotonia, impaired consciousness, irritability, malaise, myoclonus, neuralgia, psychomotor disturbance, sciatica, self-inflicted intentional injury, sleep disorder, trismus, yawning.
Neuromuscular & skeletal: Bradykinesia, dyskinesia, hyperkinetic muscle activity, hypokinesia, joint stiffness, neck stiffness.
Ophthalmic: Accommodation disturbance, blindness, iritis, miosis, mydriasis, night blindness, periorbital edema, photophobia.
Renal: Acute renal failure, glomerulonephritis, nephritis, nephrolithiasis, pyelonephritis.
Respiratory: Apnea, pulmonary edema.
Frequency not defined: Cardiovascular: Prolongation P-R interval on ECG.
Neuromuscular & skeletal: Rhabdomyolysis.
Post-marketing: Dermatologic: Maculopapular rash, toxic epidermal necrolysis (rare <1%).
Endocrine & metabolic: Gynecomastia.
Immunologic: Drug reaction with eosinophilia and systemic symptoms (rare <1%).
Respiratory: Respiratory depression.