N-Epi Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing Local Product Insert

Concise Prescribing Info

Contents

Norepinephrine bitartrate

Indications/Uses

BP control in acute hypotension.

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Dosage/Direction for Use

IV infusion Adult Initially 2-3 mL (8-12 mcg)/min. Maintenance: 0.5-1 mL (2-4 mcg)/min. Max dose: Elderly, adult, adolescent 30 mcg/min IV continuous infusion.

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Overdosage

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Contraindications

Patients who are hypotensive; w/ peripheral or mesenteric thrombosis; profound hypoxia or hypercarbia. Concomitant use w/ cyclopropane & halothane anesth.

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Warnings

For additional cautionary notes to warn of the potential risk of using the medicine... Click to view N-Epi detailed prescribing information

Special Precautions

Sulfite sensitivity in asthmatic patients. Occlusive vascular disease; preexisting hyperthyroidism or HTN. Risk of ventricular tachycardia or fibrillation during cyclopropane & halothane anesth. Monitor BP every 2 min from time of administration until desired BP is obtained, then every 5 min thereafter to avoid HTN. Avoid catheter tie-in technique; extravasation into tissues. Concomitant use w/ MAOIs, triptyline- or imipramine-type antidepressants. Hepatic & renal impairment. Pregnancy & lactation. Not recommended in childn. Not to be used into leg veins of elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Cardiac arrest & arrhythmia. HTN associated w/ bradycardia, headache, peripheral ischemia; severe tissue damage & necrosis; nausea, vomiting; confusion, tremor; anxiety, restlessness; urinary retention; dyspnea, resp difficulty; transient headache; ischemic injury; plasma vol depletion (prolonged use).

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Drug Interactions

Increased risk of severe HTN w/ non-cardioselective β-blockers. Enhanced vasopressor effect of direct acting α-/β-agonists. Enhanced effects by entacapone catechol-o-methyl transferase (COMT) inhibitors. Enhanced vasopressor effect w/ MAOIs; TCAs. Concomitant use w/ cyclopropane & halothane anesth.

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Storage

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Description

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Action

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MIMS Class

Vasoconstrictors

ATC Classification

C01CA03 - norepinephrine ; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of hypotension.

Thai FDA Category

Presentation/Packing

Form

N-Epi inj 1 mg/mL

Packing/Price

4 mL x 5 × 1's

N-Epi

norepinephrine

Manufacturer:

Novell Pharma

Distributor:

DKLL

Marketer:

Genemax Healthcare