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Gastrointestinal disorders: Nausea.
Musculoskeletal and connective tissue disorders: Bone pain.
Common: Blood and lymphatic system disorders: Thrombocytopenia, leukocytosis.
Skin and subcutaneous tissue disorders: Contact dermatitis.
Musculoskeletal and connective tissue disorders: Musculoskeletal pain (myalgia, arthralgia, pain in extremity, back pain, musculoskeletal pain, neck pain).
General disorders and administrative site conditions: Injection site pain, application site reaction, non-cardiac chest pain.
Uncommon: Blood and lymphatic system disorders: Sickle cell crisis, splenomegaly, splenic rupture.
Immune system disorders: Hypersensitivity reactions, anaphylaxis.
Metabolism and nutrition disorders: Elevations in uric acid.
Vascular disorders: Capillary leak syndrome.
Respiratory, thoracic and mediastinal disorders: Acute respiratory distress syndrome (ARDS), pulmonary adverse reaction (interstitial pneumonia, pulmonary oedema, pulmonary infiltrates and pulmonary fibrosis), haemoptysis.
Skin and subcutaneous tissue disorders: Sweet's syndrome (acute febrile dermatosis), cutaneous vasculitis.
Renal and urinary disorders: Glomerulonephritis.
General disorders and administrative site conditions: Injection site reaction.
Rare: Vascular disorders: Aortitis.
Respiratory, thoracic and mediastinal disorders: Pulmonary haemorrhage.
Skin and subcutaneous tissue disorders: Stevens-Johnson syndrome.
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