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Levofloxacin has potential to form stable compounds with many metal ions. Antacids containing aluminium or magnesium and drugs containing iron decrease absorption of Levofloxacin. The administration of these drugs are recommended at least 2 hrs before or after Levofloxacin administration.
The concomitant administration of NSAID with a quinolone including Levofloxacin, may increase the risk of CNS stimulation and convulsive seizures.
Antidiabetic agents: Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with quinolones and an antidiabetic agent. Therefore, careful monitoring of blood glucose is recommended when these agents are co-administered.
