L-Asgen 10,000 IU Caution For Usage

Incompatibilities: This medicinal product must not be mixed with other medicinal products.
Special precautions for disposal and other handling: Parenteral drugs products should be inspected visually for particulate matter and discoloration prior to administration.
For Intravenous Use: Reconstitute with sterile water for injection or with sodium chloride injection. The volume for reconstitution is 5 mL for the 10,000 IU unit vial. Ordinary shaking during reconstitution does not inactivate the enzyme. The solution may be used for direct intravenous administration with eight hour period following restoration. For administration by infusion, solutions should be diluted with isotonic solution, sodium chloride injection or dextrose injection 5%. These solutions should be infused within eight hours and only if clear.
The solution should be clear without any visible particles. Fine crystalline or thread-like wisps of protein aggregates may be visible if shaking is excessive. If there are any visible particles or protein aggregates present the reconstituted solution should be rejected.
The solution should be administered within 15 minutes of reconstitution. If a delay of more than 15 minutes between reconstitution and administration is unavoidable, the solution should be withdrawn into a glass or polypropylene syringe for the period of the delay. The solution should be used within 8 hours.
L-asparaginase is not a cytotoxic drug (such as vincristine or methotrexate) and does not require the special precautions needed for manipulating such agents.
It should be handled in the same way as other therapeutic enzymes such as hyaluronidase.
Any unused product or waste material should be disposed of in accordance with local requirements.