Kavolred Dosage/Direction for Use

Posology: Starting dose: The recommended starting dose of sevelamer carbonate is 2.4 g or 4.8 g per day based on clinical needs and serum phosphorus level. Kavolred must be taken three times per day with meals. (See Table 1.)

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For patients previously on phosphate binders (sevelamer hydrochloride or calcium based), Kavolred should be given on a gram for gram basis with monitoring of serum phosphorus levels to ensure optimal daily doses.
Titration and Maintenance: Serum phosphorus levels must be monitored and the dose of sevelamer carbonate titrated by 0.8 g three times per day (2.4 g/day) increments every 2-4 weeks until an acceptable serum phosphorus level is reached, with regular monitoring thereafter.
Patients taking sevelamer carbonate should adhere to their prescribed diets.
In clinical practice, treatment will be continuous based on the need to control serum phosphorus levels and the daily dose is expected to be an average of approximately 6 g per day.
Special populations: Elderly population: No dosage adjustment is necessary in the elderly population.
Hepatic impairment: No studies have been performed in patients with hepatic impairment.
Paediatric population: The safety and efficacy of Kavolred in children below the age of 6 years or in children with a BSA below 0.75 m² have not been established. Not data are available.
The safety and efficacy of Kavolred in children over 6 years of age and a BSA >0.75 m² have been established. Current available data are described in Pharmacology: Pharmacodynamics under Actions.
For paediatric patients the oral suspension should be administered, as tablet formulations are not appropriate for this population.
Method of administration: Oral use.
Tablets should be swallowed intact and should not be crushed, chewed, or broken into pieces prior to administration. Kavolred should be taken with food and not on an empty stomach.