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Probenecid causes 2-fold reduction in clearance of paracetamol by inhibiting its conjugation with glucuronic acid. Thus, paracetamol dose should be reduced in case of combined treatment with probenecid.
Salicylates may prolong elimination half-life of paracetamol.
Liver microsomal oxidation inducing agents (such as phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) may enhance development of severe toxicity following even insignificant overdose.
