Ilumya Dosage/Direction for Use

Recommended Dose: The recommended dosage is 100 mg at Weeks 0, 4, and every 12 weeks thereafter. Each syringe contains 1 mL of 100 mg/mL tildrakizumab.
Tuberculosis Assessment Prior to Initiation of ILUMYA: Evaluate patients for tuberculosis (TB) infection prior to initiating treatment with ILUMYA (see Precautions).
Mode of Administration: ILUMYA is administered by subcutaneous injection. Injection sites should be alternated. ILUMYA should not be injected into areas where the skin is affected by plaque psoriasis or is tender, bruised, red, hard, thick, or scaly. The prefilled syringe must not be shaken. Each prefilled syringe is for single use only.
Inject the full amount of tildrakizumab according to the instructions for use provided in the package insert.
After proper training in subcutaneous injection technique, patients may self-inject ILUMYA if a physician determines that it is appropriate. However, the physician should ensure appropriate follow-up of patients. Patients should be instructed to inject the full amount of ILUMYA according to the instructions provided in the package leaflet. Comprehensive instructions for administration are given in the package insert.
Preparation and Administration of ILUMYA: Before injection, remove ILUMYA carton from the refrigerator, and let the prefilled syringe (in the ILUMYA carton with the lid closed) sit at room temperature for 30 minutes.
Follow the instructions on the ILUMYA carton to remove the prefilled syringe correctly, and remove only when ready to inject. Do not pull off the needle cover until ready to inject.
Inspect ILUMYA visually for particulate matter and discoloration prior to administration. ILUMYA is a clear to slightly opalescent, colorless to slightly yellow solution. Do not use if the liquid contains visible particles or the syringe is damaged. Air bubbles may be present; there is no need to remove them.
Choose an injection site with clear skin and easy access (such as abdomen, thighs, or upper arm). Do not administer 2 inches around the navel or where the skin is tender, bruised, erythematous, indurated, or affected by psoriasis. Also do not inject into scars, stretch marks, or blood vessels.
While holding the body of the syringe, pull the needle cover straight off (do not twist) and discard.
Inject ILUMYA subcutaneously as recommended (see as previously mentioned).
Press down the blue plunger until it can go no further. This activates the safety mechanism that will ensure full retraction of the needle after the injection is given.
Remove the needle from the skin entirely before letting go of the blue plunger. After the blue plunger is released, the safely lock will draw the needle inside the needle guard.
Discard any unused portion. Dispose of used syringe.