The maximum amount of Hemax that can be safety administered in a single dose or through infusion has not been determined yet. Doses of up to 1500 U/Kg TIW or up to 60,000 IU/week have been administered to adults without any direct toxic effects. Therapy with Hemax can result in polyglobulia and patients may experience polyglobulia related symptoms, such as headaches, somnolence, tinnitus, dizziness, etc. In this case, it is advisable to perform a phlebotomy aiming at reducing the haematocrit. In case of overdose, attend the closest hospital or phone any Toxicology Centre.