OVERDOSE AND TREATMENT: The maximum amount of Epoetin alfa that can be safely administered has not been determined. Erythropoietin doses of up 1500 IU/kg for three times a week have been administered without any direct toxic effect. This therapy can result in polycythemia if the hematocrit is not carefully monitored and the dose is not appropriately adjusted. If the hematocrit's value exceeds expected, treatment may be interrupted or maintain by using low doses.