Forteo Drug Interactions

FORTEO has been evaluated in pharmacodynamic interaction studies with hydrochlorothiazide. No clinically significant interactions were noted.
Co-administration of raloxifene or hormone replacement therapy with FORTEO did not alter the effects of FORTEO on serum or urine calcium or on clinical adverse events.
In a study of 15 healthy subjects administered digoxin daily to steady state, a single FORTEO dose did not alter the cardiac effect of digoxin. However, sporadic case reports have suggested that hypercalcemia may predispose patients to digitalis toxicity. Because FORTEO transiently increases serum calcium, FORTEO should be used with caution in patients taking digitalis.
Laboratory Values: Serum Calcium: Teriparatide can induce small, transient increases in serum calcium. If serum calcium is to be assessed, blood samples should be obtained at least 16 hrs after the most recent teriparatide injection to allow waning of the effects of administered teriparatide.
Urinary Calcium: Teriparatide may cause small increases in urinary calcium excretion, but the incidence of hypercalciuria did not differ from that in the placebo-treated patients in clinical trials.