Adult/elderly Initially 5 mg once daily. Dose may be increased to 10 mg/day, following a 1-mth clinical assessment. Max: 10 mg once daily. Patients w/ DLB Dose may be decreased to 5 mg depending on the symptoms.
Severe Alzheimer's dementia, other types of dementia or other types of memory impairment (eg, age-related cognitive decline). Concomitant use w/ anesth. May have vagotonic effects on heart rate (eg, bradycardia); bladder outflow obstruction. Monitor patients who are at risk for developing ulcers eg, history of ulcer disease or receiving concurrent NSAIDs. Potential to exacerbate or induce extrapyramidal symptoms. Discontinue treatment if NMS occurs. History of asthma or obstructive pulmonary disease. Avoid concomitant use w/ other acetylcholinesterase inhibitors, cholinergic system agonists or antagonists. Severe hepatic impairment. May impair ability to drive or use machines. Pregnancy & lactation. Childn & adolescents <18 yr.
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