OVERDOSE AND TREATMENT: There is no reported direct experience of human overdose and no specific antidote. However, early clinical study data in published literature at doses greater than 20 times higher than the current therapeutic doses, reported increased myelosuppression including prolonged neutropenia and thrombocytopenia. Toxicity is likely to manifest as exacerbations of adverse reactions, primarily myelosuppression (see ADVERSE REACTIONS). Treatment for overdose should be supportive.