Coversyl Arginine Drug Interactions

Please tell the doctor or pharmacist if the patient is taking, has recently taken or might take any other medicines.
Treatment with Coversyl can be affected by other medicines. The doctor may need to change the dose and/or to take other precautions. These include: other medicines for high blood pressure, including angiotensin II receptor blocker (ARB), aliskiren (see also information under "Contraindications" and "Precautions"), or diuretics (medicines which increase the amount of urine produced by the kidneys); potassium-sparing drugs (e.g. triamterene, amiloride), potassium supplements or potassium-containing salt substitutes, potassium-sparing drugs used in the treatment of heart failure: eplerenone and spironolactone at doses between 12.5 mg to 50 mg by day; lithium for mania or depression; non-steroidal anti-inflammatory drugs (e.g. ibuprofen) for pain relief or high dose aspirin; medicines to treat diabetes (such as insulin or metformin); baclofen (used to treat muscle stiffness in diseases such as multiple sclerosis); medicines to treat mental disorders such as depression, anxiety, schizophrenia etc (e.g. tricyclic antidepressants, antipsychotics); immunosuppressants (medicines which reduce the defence mechanism of the body) used for the treatment of auto-immune disorders or following transplant surgery (e.g. ciclosporin, tacrolimus); trimethoprim (for the treatment of infections); estramustine (used in cancer therapy); Racecadotril: ACE inhibitors (e.g. perindopril) are known to cause angioedema. This risk may be elevated when used concomitantly with racecadotril (a drug used against acute diarrhea); mTOR inhibitors (e.g. sirolimus, everolimus, temsirolimus): Patients taking concomitant mTOR inhibitors therapy may be at increased risk for angioedema (see "Precautions"); allopurinol (for the treatment of gout); procainamide (for the treatment of an irregular heart beat); vasodilators including nitrates (products that make the blood vessels become wider); heparin (medicines used to thin blood); medicines used for the treatment of low blood pressure, shock or asthma (e.g. ephedrine, noradrenaline or adrenaline); gold salts, especially with intravenous administration (used to treat symptoms of rheumatoid arthritis).
Extracorporeal treatments: Extracorporeal treatments leading to contact of blood with negatively charged surfaces such as dialysis or haemofiltration with certain high-flux membranes (e.g. polyacrylonitrile membranes) and low density lipoprotein apheresis with dextran sulphate due to increased risk of severe anaphylactoid reactions (see "Contraindications"). If such treatment is required, consideration should be given to using a different type of dialysis membrane or a different class of antihypertensive agent.
Sacubitril/Valsartan: The concomitant use of perindopril with sacubitril/valsartan is contra-indicated as the concomitant inhibition of neprilysin and ACE may increase the risk of angioedema. Sacubitril/valsartan must not be started until 36 hours after taking the last dose of perindopril therapy. Perindopril therapy must not be started until 36 hours after the last dose of sacubitril/valsartan (see "Contraindications" and "Precautions").
Co-trimoxazole (trimethoprim/sulfamethoxazole): Patients taking concomitant co-trimoxazole (trimethoprim/sulfamethoxazole) may be at increased risk for hyperkalaemia (see "Precautions").