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Each tablet contains 0.6 mg colchicine. The tablets also contain lactose, magnesium stearate, and starch.
A phenanthrene derivative, colchicine is the active alkaloidal principle derived from various species of Colchicum; it appears as pale-yellow amorphous scales or powder that darkens on exposure to light. One g dissolves in 25 ml of water and in 220 ml of ether. Colchicine is freely soluble in alcohol and chloroform.
Colchicine, an acetyltrimethylcolchicinic acid, is hydrolyzed in the presence of dilute acids or alkalies, with cleavage of a methyl group as methanol and formation of colchiceine, which has very little therapeutic activity. On hydrolysis with strong acids, colchicine is converted to trimethylcolchicinic acid.
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