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Mechanism of action: Clindamycin is a lincosamide antibiotic with a primarily bacteriostatic action against gram-positive including streptococci, staphylococci, Bacillus anthracis, and Corynebacterium diphtheriae and a wide range of anaerobic bacteria. Susceptible gram-positive anaerobes including Eubacterium, Propionibacterium, Peptococcus, and Peptostreptococcus spp., and many strains of Clostridium perfringens and Cl. tetani. Among Gram-negative anaerobes susceptible to clindamycin are Fusobacterium spp., Veillonella, and Bacteroides spp., including the B. fragilis group.
Clindamycin is usually considered bacteriostatic by binding to the 50 S subunits of bacterial ribosomes and preventing peptide bond formation, cause inhibition of protein synthesis in susceptible bacteria. Clindamycin may be bactericidal in high concentrations. When used against highly susceptible organisms Clindamycin may be bactericidal antibiotic.
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