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The serious effects of Lidocaine toxicity are on the CNS and CVS such as severe hypotension, asystole, bradycardia, apnoea, seizures, coma, cardiac arrest, respiratory arrest and death.
Severe neurological symptoms (convulsions, CNS depression) must be treated symptomatically by respiratory support and the administration of anticonvulsant drugs.
If circulatory arrest should occur, immediate cardiopulmonary resuscitation should be instituted.
Optimal oxygenation and ventilation and circulatory support as well as treatment of acidosis are of vital importance.
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