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Capecitabine is contraindicated in patients with a known hypersensitivity to capecitabine or to any of its excipients.
Capecitabine is contraindicated in patients who have a history of severe and unexpected reactions to fluoropyrimidine therapy or with known hypersensitivity to fluorouracil.
Capecitabine is contraindicated in patients with known complete absence of dihydropyrimidine dehydrogenase (DPD) activity (see WARNINGS).
Capecitabine should not be administered concomitantly with sorivudine or its chemically related analogues, such as brivudine (see INTERACTIONS).
Capecitabine is contraindicated in patients with severe renal impairment (creatinine clearance below 30 mL/min).
If contraindications exist to any of the agents in a combination regimen, that agent should not be used.
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