Avastin Caution For Usage

Special Instructions for Use, Handling and Disposal: Avastin infusions should not be administered or mixed with dextrose or glucose solutions (see "Incompatibilities" as follows).
Do not administer as an intravenous push or bolus.
Avastin should be prepared by a healthcare professional using aseptic technique. Use sterile needle and syringe to prepare Avastin. Withdraw the necessary amount of bevacizumab and dilute to the required administration volume with 0.9% sodium chloride solution. The concentration of the final bevacizumab solution should be kept within the range of 1.4-16.5 mg/ml.
Discard any unused portion left in a vial, as the product contains no preservatives. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration.
Avastin is not formulated for intravitreal use.
Incompatibilities: No incompatibilities between Avastin and polyvinyl chloride or polyolefin bags have been observed. A concentration-dependent degradation profile of Avastin was observed when diluted with dextrose solutions (5%).
Disposal of unused/expired medicines: The release of pharmaceuticals in the environment should be minimized. Medicines should not be disposed of via wastewater and disposal through household waste should be avoided. Use established "collection systems", if available in the location.