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In clinical studies the side-effects reported are usually attributable to its pharmacological actions and include coldness of the extremities, muscular fatigue and, in isolated cases, bradycardia. There have been reports of skin rashes and/or dry eyes associated with the use of beta adrenergic blocking drugs.
The reported incidence is small and in most cases the symptoms have cleared when treatment was withdrawn. Discontinuance of the drug should be considered if any such reaction is not otherwise explicable. Cessation of therapy with a beta-adrenergic blocker should be gradual.
