Adult Shingles (herpes zoster) 1,000 mg tds for 7 days.
Herpes simplex infections 500 mg bd for 5 days (recurrent infections) & 10 days (severe initial episodes).
Prophylaxis of recurrences of herpes simplex infections Immunocompetent:
500 mg once daily. Immunocompromised: 500 mg bd.
Renal impairment Herpes zoster CrCl at least 50 mL/min 1 g tds,
30-49 mL/min 1 g bd,
10-29 mL/min 1 g once daily,
<10 mL/min 500 mg once daily.
Herpes simplex CrCl at least 30 mL/min 500 mg bd,
<30 mL/min 500 mg once daily.
Herpes simplex prevention Adult Immunocompetent:
CrCl at least 30 mL/min 500 mg once daily,
<30 mL/min 250 mg once daily. Immunocompromised:
CrCl at least 30 mL/min 500 mg bd,
<30 mL/min 500 mg once daily.
Reduction of genital herpes transmission CrCl at least 30 mL/min 500 mg once daily,
<30 mL/min 250 mg once daily.
Sign Out
