Trusopt Drug Interactions

Specific drug interaction studies have not been performed with Trusopt. In clinical studies, it was used concomitantly with the following medications without evidence of adverse interactions: Timolol ophthalmic solution, betaxolol ophthalmic solution and systemic medications, including ACE inhibitors, calcium-channel blockers, diuretics, nonsteroidal anti-inflammatory drugs including aspirin and hormones (eg, estrogen, insulin, thyroxine).
Trusopt is a carbonic anhydrase inhibitor and although administered topically, is absorbed systemically. In clinical studies, it was not associated with acid-base disturbances. However, these disturbances have been reported with oral carbonic anhydrase inhibitors and have in some instances, resulted in drug interactions (eg, toxicity associated with high-dose salicylate therapy). Therefore, the potential for such drug interactions should be considered in patients receiving Trusopt.