Hypersensitivity to the active substance or to any of the excipients listed in Description.
Second and third trimester of pregnancy (see Precautions and Use in Pregnancy & Lactation).
Biliary obstructive disorders.
Severe hepatic impairment.
Lactation.
In case of rare hereditary conditions that may be incompatible with an excipient of the product (refer to Precautions) the use of the product is contraindicated.
The concomitant use of Tolura with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR <60 ml/min/1.73 m2) (see Pharmacology: Pharmacodynamics under Actions and Interactions).