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Although Timoptol used alone has little or no effect on pupil size, mydriasis resulting from concomitant therapy with Timoptol and epinephrine has been reported occasionally.
Potentiated systemic β-blockade (e.g., decreased heart rate) has been reported during combined treatment with CYP2D6 inhibitors (e.g., quinidine and SSRIs) and timolol.
The potential exists for additive effects and production of hypotension and/or marked bradycardia when TIMOPTOL is administered together with an oral calcium-entry blocker, catecholamine-depleting drugs, antiarrhythmics, parasympathomimetics or β-adrenergic-blocking agents.
Oral β-adrenergic blocking agents may exacerbate the rebound hypertension which can follow the withdrawal of clonidine.
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