TachoSil Description

TachoSil is a biodegradable, highly flexible, hygroscopic surgical medicated sponge. The active side of the sponge, which is coated with fibrinogen and thrombin, is marked by a yellow colour. Each TachoSil sponge contains approximately 5.5 mg of human fibrinogen and 2.0 IU of human thrombin per cm² as the active ingredients.
The active components of TachoSil medicated sponge are human fibrinogen and human thrombin.
Fibrinogen is a soluble plasma glycoprotein with a molecular weight of approximately 340 kDa, and circulates in plasma as a precursor of fibrin. The native molecule is a homodimer, in which both subunits consist of three different polypeptide chains (Aα, Bβ, and γ).
All three polypeptide chains of the subunits as well as the dimer are linked with disulfide bonds. Thrombin is a serine protease with a molecular weight of approximately 39 kDa and consists of 295 amino acids. It is formed by two peptide chains of 36 and 259 amino acids respectively, linked by disulfide bonds.
TachoSil is available in three presentations, which differ in the size of the sponge, but not in the composition of the sponge and the coating (see Presentation and Storage).
Excipients/Inactive Ingredients: Other inactive ingredients include riboflavine, equine collagen, human albumin, sodium chloride, sodium citrate and arginine hydrochloride.