Sunflu Overdosage

Symptoms and treatment of overdosage: Phenylephrine hydrochloride: Overdosage may induce ventricular extrasystoles and short paroxysms of ventricular tachycardia, a sensation of fullness in the head and tingling of the extremities. Should an excessive elevation of blood pressure occur, it may be immediately relieved by an adrenergic blocking agent.
Chlorpheniramine Maleate: Antihistamine overdosage may vary from central nervous system depression (sedation, apnea, cardiovascular collapse) to stimulation (insomnia, hallucinations, tremors or convulsions). Other signs and symptoms may be dizziness, tinnitus, ataxia, blurred vision and hypotension. Stimulation and atropine-like signs and symptoms (dry mouth, fixed, dilated pupils, flushing, hyperthermia and gastrointestinal symptoms) are particularly likely in children.
Treatment: Emergency treatment should be started immediately. Vomiting should be induced, even if it has occurred spontaneously. Vomiting by administration of ipecac syrup is preferred. Vomiting should not be induced in patients with impaired consciousness. The action of ipecac is facilitated by physical activity and by the administration of eight to twelve fluid ounces of water. If emesis does not occur within fifteen minutes, the dose of ipecac should be repeated. Precautions against aspiration must be taken, especially in infants and children. Following emesis, any drug remaining in the stomach may be absorbed by activated charcoal administered as a slurry with water. If vomiting is unsuccessful, or contraindicated, gastric lavage should be performed. Isotonic or half isotonic saline are the lavage solution of choice. Saline cathartics, such as milk of magnesia, draw water into the bowel by osmosis and therefore, may be valuable for their action in rapid dilution of bowel content. After emergency treatment the patient should continue to be medically monitored.
Treatment of signs and symptoms of overdosage is symptomatic and supportive.
Stimulants should not be used.
Vasopressors may be used to treat hypotension.
Short-acting barbiturates, diazepam or paraldehyde may be administered to control seizures.
Hyperpyrexia, especially in children, may require treatment with tepid water sponges baths or a hypothermia blanket. Apnea is treated with ventilatory support.