Immediate hypersensitivity reactions may occur. Not to be used more frequently than once daily. Not to be used in asthma; may increase risk of asthma-related hospitalisations & death. Not indicated for acute episodes of bronchospasm (ie, rescue therapy). Immediately discontinue use & substitute alternative therapy if paradoxical bronchospasm occurs. Patients w/ narrow-angle glaucoma, prostatic hyperplasia or bladder-neck obstruction. Avoid contact w/ eyes; discontinue use if precipitation or worsening of narrow-angle glaucoma, eye pain or discomfort, temporary vision blurring, visual halos or coloured images in association w/ red eyes from conjunctival congestion & corneal oedema occur. Possible dry mouth associated w/ dental caries (long-term use). Patients w/ CV disorders especially coronary insufficiency, cardiac arrhythmias, hypertrophic obstructive cardiomyopathy, HTN; convulsive disorders or thyrotoxicosis, known or suspected QT interval prolongation & in those who are unusually responsive to sympathomimetic amines. Discontinue treatment if increased pulse rate, BP &/or symptoms occur. History of MI during previous yr, unstable or life-threatening cardiac arrhythmia, hospitalized for heart failure during previous yr, or w/ diagnosis of paroxysmal tachycardia (>100 beats/min). Possible hypokalaemia; may be potentiated by hypoxia in patients w/ severe COPD. May increase plasma glucose. Not to be used in conjunction w/ long-acting β
2-adrenergic agonists or long-acting muscarinic antagonists. Contains benzalkonium Cl which may cause wheezing & breathing difficulties. Moderate to severe renal impairment (CrCl ≤50 mL/min). Severe hepatic impairment. Avoid potentially hazardous tasks eg, driving or operating machinery if dizziness & blurred vision occur. Avoid use during pregnancy. Lactation. Childn.
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