Sifrol Drug Interactions

Plasma protein binding: Pramipexole is bound to plasma proteins to a very low (<20%) extent and little biotransformation is seen in man. Therefore, interactions with other medication affecting plasma protein binding or elimination by biotransformation are unlikely.
Inhibitors or competitors of active renal elimination pathway: Medication that inhibit the active renal tubular secretion of basic (cationic) drugs, such as cimetidine, or are themselves eliminated by active renal tubular secretion, may interact with SIFROL resulting in reduced clearance of either or both medication. In case of concomitant treatment with these kinds of drugs (incl. amantadine) attention should be paid to signs of dopamine over stimulation, such as dyskinesias, agitation or hallucinations. In such cases a dose reduction is necessary.
Pharmacokinetic interactions with selegiline or levodopa: Selegiline and levodopa do not influence the pharmacokinetics of pramipexole. The overall extent of absorption or elimination of levodopa is not changed by pramipexole.
Anticholinergic agents or amantadine: As anticholinergics are mainly eliminated by hepatic metabolism, pharmacokinetic drug-drug interactions with pramipexole are rather unlikely. With amantadine, an interaction is possible via the same system of excretion in the kidney. The interaction with anticholinergics and amantadine has not been examined.
Dopamine antagonists: Co-administration of pramipexole with antipsychotics (e.g. phenothiazines, butyrophenones, thioxanthenes) or other centrally active dopamine antagonists such as metoclopramide is not recommended, e.g. if dopamine-antagonistic effects can be expected. (See Precautions.)
Effect of pramipexole on levodopa or other antiparkinsonian medication: While increasing the dose of SIFROL in Parkinson's disease patients it is recommended that the dosage of levodopa is reduced and the dosage of other antiparkinsonian medication kept constant.
Sedative medicinal products or alcohol: Because of possible additive effects, caution should be advised when patients are taking other sedating medication or alcohol in combination with SIFROL and when taking concomitant medication that increase plasma levels of pramipexole (e.g., cimetidine).