Rimegepant - Oral

Rimegepant is used to treat and prevent migraine attacks (severe throbbing pain or pulsating sensation usually affecting one side of the head that is often accompanied by nausea, vomiting, and sensitivity to light and sound).

Take Rimegepant exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food.

Rimegepant is available as an orally disintegrating (orodispersible) tablet.

To take the orodispersible tablet, follow these steps:

1. Using your dry hands, peel back the foil covering of the blister, then gently remove the orodispersable tablet. Do not push the orodispersible tablet through the foil as it is fragile and easily broken.
2. Place the orodispersible tablet directly on or under your tongue as soon as it is taken out of the foil. It will immediately start to melt in your mouth, no drink or water is needed.

Do not cut, break, or crush the orodispersible tablet.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the course of treatment depending on your condition or response to the medication.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.

Do not take this medicine if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with Rimegepant, alert your doctor immediately.

Inform your doctor if you have the following conditions:

• severe kidney disease
• severe liver disease

Let your doctor know if you are breastfeeding.

Why is it important to keep my appointments with the doctor?

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.

• Monitoring for signs and symptoms of medication overuse headache (MOH) (frequent or daily headaches despite [or because of] regular use of medicines for headache) may be done while you are being treated with this medicine.
• Regular monitoring for signs and symptoms of allergic reactions may also be needed.

Rimegepant may cause any of the following side effects: nausea, vomiting, and indigestion.

If you develop rashes, breathlessness, swollen mouth or eyes, stop taking this medicine and inform your doctor immediately. These could be signs of an allergic reaction.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.

Do not take Rimegepant more than once in 48 hours with the following medicines:

• medicines for irregular heartbeat e.g. amiodarone, quinidine
• medicines for high blood pressure e.g. diltiazem, verapamil
• fluconazole (medicine used to treat fungal infection)
• erythromycin (certain antibiotic)
• ciclosporin (medicine used in organ transplants or certain immune disorders)
• lapatinib (medicine for cancer)
• ranolazine (medicine for chest pain)

Inform your doctor and pharmacist if you are taking any of these medicines:

• medicines for HIV infection e.g. ritonavir, efavirenz
• clarithromycin (certain antibiotic)
• itraconazole (medicine used to treat fungal infection)
• rifampicin (medicine to treat TB, an infection known as tuberculosis)
• phenobarbital (medicine for fits or seizures)
• bosentan (medicine for high blood pressure in the blood vessels leading to the lungs)
• modafinil (medicine for sleep disorder)
• St. John's wort (herbal medicine)

This list does not include all medicines that may interact with Rimegepant.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.

Avoid alcohol.

Store in a cool, dry place away from the reach of children.

The orodispersible tablet must be kept in its original foil wrapper and original container. Do not store this medicine in any other container except its original.

Medicines must not be used past the expiry date.